Knowledge Sharing

Recently, Ivonescimab Injection, independently developed by Akeso-Sino Biopharmaceutical Co., Ltd. and the world's first of its kind, has been officially approved for marketing. Combined with chemotherapy, Ivonescimab Injection is expected to provide a brand-new and highly effective immunotherapeutic regimen for patients with locally advanced or metastatic non-squamous non-small cell lung cancer.

Pathogenic microorganisms cause various infectious diseases. Major outbreaks like Ebola, COVID-19, and malaria threaten human health and trigger social crises, driving the search for simpler, more effective treatments. Controlling infection sources, blocking transmission, and protecting vulnerable groups are key to prevention and control.

Since their discovery, nanobodies have been widely applied in fields such as tumor/neurological disease research and imaging diagnosis. In recent years, researchers have gradually expanded their application to more domains, including food safety and environmental hygiene testing. Recently, researchers have conducted studies on the application of nanobodies in animal husbandry.

Social development is closely linked to the labor force. Workers contribute wisdom, skills, and efforts, driving progress in science, technology, and culture. With technological and cultural advancement, people’s lifestyles are constantly changing. Rapid social development has led modern people to pursue a more structured and efficient life. Yet, the neglect of spiritual needs has resulted in a sharp rise in the incidence of mental health problems.

Aflatoxins are a group of compounds characterized by a basic structure containing a dihydrofuran ring and coumarin (oxygenated naphthalene ketone). Their presence poses a serious threat to food safety, with risks to human health that cannot be ignored. Therefore, the detection of aflatoxins is crucial in the food safety production process.

Asthma is a common chronic respiratory disease with complex, heterogeneous pathogenesis. Traditionally classified as exogenous or endogenous, both types involve mast cells, eosinophils, cytokines, and inflammatory mediators. Current treatments focus on symptom control, attack prevention, and quality of life improvement.

Directed immobilization technology immobilizes target molecules or substances on specific sites or carriers via dedicated methods and materials. It is widely applied in biomedicine, materials science, and environmental monitoring. This technology can effectively improve detection efficiency, reduce workload and research costs, and has been widely adopted and studied as an efficient strategy in various scientific fields.

Targeted Protein Degradation (TPD) technology has rapidly evolved over the past two decades as a method to disrupt protein function. The aim of this technology is to selectively degrade specific proteins, thereby modulating cellular processes and signaling pathways.

Nanobodies are promising tools for targeted detection and clinical therapy. Current research on Helicobacter pylori (HP) targeting mainly focuses on peptides, scFv, yolk antibodies, and monoclonal antibodies. Although nanobodies have high affinity, good stability, low immunogenicity, small size, and easy modification, effective HP-targeted nanobody drugs have not been well developed.

Recently, Johnson & Johnson (JNJ) announced that its developed bispecific antibody, Rybrevant (amivantamab), has received full approval from the U.S. FDA for its use in combination with chemotherapy (carboplatin and pemetrexed) for the first-line treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) patients.

Winter is the peak season for acute cardiovascular and cerebrovascular events. Cold weather raises blood pressure and induces cerebral vasospasm, increasing the risk of stroke, myocardial infarction and sudden cardiac death. Research shows that every 1°C drop in temperature raises heart disease incidence by about 2%. Traditional treatments remain limited despite common approaches like fat reduction and vessel dilation.

Diabetes, referred to as 'Xiaoke syndrome' in traditional Chinese medicine in China, has been documented in classic Chinese medical texts such as the 'Huangdi Neijing' and 'Lingshu' as early as around 400 BC. It refers to type 2 diabetes mellitus (T2DM), characterized by symptoms such as polydipsia, polyphagia, polyuria, as well as emaciation, fatigue, and sweet urine.